![]() ![]() This involves exploring different methods of isolation. One area of interest for the induction of natural products through co-culture microbial communication through small molecules.Ĭurrently, we have explored some microbial interactions within co-culture conditions, but need to develop a way to discover the small molecules utilized in the microbial communication process. This discovery has sparked significant interest in probing microbial genomes for new and bioactive natural products. ![]() Over the last decade, analysis of microbial genomes has demonstrated that only a fraction of the possible microbial secondary metabolites have been explored. However, the difficulty in discovery and isolation of natural products has caused a shift in development of pharmaceutical drug leads (i.e. Since 1980, greater than 60% of drugs developed were derived from natural sources. Secondary metabolites (natural products) have had a long, rich history with respect to their importance in the treatment of disease. Project 2: Elucidating Changes in Antimicrobial Production of Streptomyces sps. This project applies proton nuclear magnetic resonance ( 1H-NMR) and visible spectroscopy as means to monitoring the weak acid-weak base interaction and to quantify the pK a by proton integration and wavelength absorbance changes, respectively. ![]() Challenges in determining the pKa’s of these ligands include monitoring the equilibrium of a weak acid-weak base chemical reaction and the use of different methods in determining the acidity of a proton in organic solvent conditions, since common aqueous methods are not possible. Our project’s goal is to quantify the changes in pK a of previously synthesized glycine containing ligands with the presence or absence of electron withdrawing groups attached to the molecule in organic solvents. The use of electron withdrawing groups is a well-known approach to change the chemical properties of a molecule, including the acidity. Project 1: Method Development and Determination of Glycine Metal Complex pKa’s by NMR and Visible Spectroscopy Chemistry and Biochemistry, University of Oklahoma Chemistry and Biochemistry, University of OklahomaĢ011 – Ph.D. Chemistry, Emporia State UniversityĢ009 – M.S. ![]()
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